Selank Overview Selank is a synthetic heptapeptide structurally derived from the endogenous immunomodulatory peptide tuftsin. Supplied as a lyophilized powder, it is utilized in controlled laboratory environments to study neuroregulatory pathways, neurotransmitter modulation, and enkephalinase inhibition. Kiyora supplies Selank strictly for laboratory and research use only. This content is presented for educational and informational context and is not intended as medical advice or a therapeutic claim.

What Is Selank? Selank is an artificially synthesized seven-amino-acid peptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro). It consists of the core tuftsin sequence extended by a Pro-Gly-Pro motif at the C-terminus. This specific structural modification enhances the peptide's metabolic stability and resists rapid enzymatic degradation, allowing researchers to observe extended neurotropic and immunomodulatory signaling kinetics in experimental settings compared to native tuftsin.

How Does Selank Work? Research to date has investigated Selank in connection with central nervous system (CNS) function and neuro-immune crosstalk. While exact downstream pathways remain under ongoing scientific investigation, the compound is frequently referenced in laboratory literature for the following areas:

GABAergic Signaling Modulation In cellular and animal models, Selank is utilized to observe interactions with GABA_A receptors. Research suggests it may influence the allosteric modulation of these receptors, affecting the central pathways associated with inhibitory neurotransmission and stress responses.

Neurotransmitter & Neurotrophic Factor Expression Researchers use Selank to study the expression of Brain-Derived Neurotrophic Factor (BDNF) and the modulation of monoamine metabolism. Experimental assays evaluate how the peptide influences the levels and turnover rates of serotonin, dopamine, and norepinephrine in controlled environments.

Enkephalinase Inhibition Secondary experimental models explore Selank’s ability to inhibit enzymes responsible for degrading endogenous enkephalins. By stabilizing these natural regulatory peptides, researchers can isolate and study prolonged enkephalin signaling pathways in the laboratory.

Selank Research The following topics reflect areas where Selank has been discussed in research literature and educational summaries. This section is for informational and laboratory context only.

• Selank and Neurobiological Assays: The product is best described as a research supply for studying synaptic plasticity, stress-induced neurotransmitter fluctuations, and cellular neurochemistry.

• Selank and Immunomodulation: It is commonly referenced in research isolating tuftsin-like effects on immune function, particularly regarding the expression of cytokines like IL-6 during cellular stress models.

Technical Specifications

• Compound: Selank (Tuftsin analog)

• Presentation: Lyophilized solid

• Category: Research Peptides

• Use: Laboratory research use only

Handling and Storage Store the lyophilized peptide under appropriate laboratory conditions, ideally at -20°C (or -80°C for long-term storage) to preserve sequence integrity. Protect from excess heat, direct light, and moisture, and follow standard sterile handling procedures. Reconstitute using an appropriate sterile diluent (such as Bacteriostatic Water) immediately prior to laboratory use. Once reconstituted, store liquid aliquots at 2°C to 8°C for short-term handling, or freeze at -20°C. Avoid repeated freeze-thaw cycles to prevent degradation of the peptide chain.

COA (Certificate of Analysis) Every batch of Selank is subjected to rigorous analytical testing to ensure research-grade quality and reproducibility in sensitive experimental models:

• HPLC Purity: Assessed at ≥98% to verify the absence of synthesis truncations and impurities, ensuring reliable data in sensitive neurobiological assays.

• Mass Spectrometry (MS): Molecular weight verification confirming the exact structural identity and heptapeptide sequence of the analog.

• Endotoxin Testing: Verified via LAL (Limulus Amebocyte Lysate) assay to ensure endotoxin levels remain below critical thresholds, preventing unwanted inflammatory responses in in vitro cellular testing.

Disclaimer This information is for educational and informational purposes only and does not constitute medical advice. This product is intended strictly for laboratory and research use only. It is not a drug, not for human or veterinary use, diagnostic use, therapeutic use, or personal consumption.

All research should be conducted by qualified professionals using appropriate oversight, laboratory controls, and applicable institutional standards. Users should independently review and verify all information from trusted scientific sources before relying on it in any research context.